Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis.
The balance between T helper (Th) 1 and Th2 cell responses is a major determinant of the outcome of experimental leishmaniasis, but polarized Th1 or Th2 responses are not sufficient to account for healing or nonhealing.Here we show that high arginase activity, a hallmark of nonhealing disease, is primarily expressed locally at the site of pathology